期刊
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
卷 74, 期 1, 页码 44-50出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp.74.1.44
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资金
- NIA NIH HHS [AG 08441, P01 AG 04953] Funding Source: Medline
- NIMH NIH HHS [MH 60941] Funding Source: Medline
- NINDS NIH HHS [K23 NS 02189] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH060941] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K23NS002189] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG004953, R37AG008441, R01AG008441] Funding Source: NIH RePORTER
Objective: To examine alterations in patterns of brain activation seen in normal aging and in mild Alzheimer's disease by functional magnetic resonance imaging (fMRI) during an associative encoding task. Methods: 10 young controls, 10 elderly controls, and seven patients with mild Alzheimer's disease were studied using fMRI during a face-name association encoding task. The fMRI paradigm used a block design with three conditions: novel face-name pairs, repeated face-name pairs, and visual fixation. Results: The young and elderly controls differed primarily in the pattern of activation seen in prefrontal and parietal cortices: elderly controls showed significantly less activation in both superior and inferior prefrontal cortices but greater activation in parietal regions than younger controls during the encoding of novel face-name pairs. Compared with elderly controls, the Alzheimer patients showed significantly less activation in the hippocampal formation but greater activation in the medial parietal and posterior cingulate regions. Conclusions: The pattern of fMRI activation during the encoding of novel associations is differentially altered in the early stages of Alzheimer's disease compared with normal aging.
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