期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 377, 期 5, 页码 820-825出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-003-2144-2
关键词
PCR microchip; miniaturization; DNA
Miniaturization of genetic tests has become an important goal. This review surveys the current progress towards the miniaturization of tests based on the polymerase chain reaction (PCR). It examines the different types of PCR microchip designs, fabrication methods, and the components of a microchip PCR device. It also discusses the problems attributable to surface chemistry of microchip components ( inhibition of PCR), and the static and dynamic surface passivation strategies developed for the solution of these difficulties.
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