期刊
DEVELOPMENT
卷 130, 期 21, 页码 5179-5190出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.00732
关键词
mesenchyme; notochord; induction; responsiveness; intrinsic factor; macho-1; FGF; snail; ascidian
An extracellular signaling molecule acts on several types of cells, evoking characteristic and different responses depending on intrinsic factors in the signal-receiving cells. In ascidian embryos, notochord and mesenchyme are induced in the anterior and posterior margins, respectively, of the vegetal hemisphere by the same FGF signal emanating from endoderm precursors. The difference in the responsiveness depends on the inheritance of the posterior-vegetal egg cytoplasm. We show that macho-1, first identified as a localized muscle determinant, is also required for mesenchyme induction, and that it plays a role in making the cell response differ between notochord and mesenchyme induction. A zygotic event involving snail expression downstream of maternal macho-1 mediates the suppression of notochord induction in mesenchyme precursors.
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