期刊
CELL BIOLOGY INTERNATIONAL
卷 33, 期 11, 页码 1127-1134出版社
WILEY
DOI: 10.1016/j.cellbi.2009.07.005
关键词
Human bone marrow mesenchymal stem cells; Immunomodulation; T-cells; Antheraea pernyi silk fibroin; Silk
类别
资金
- China National 973'' Program [2005CB623906]
- Shangdong Province Natural Science Foundation of China [Y2006C02]
- National Defence Foundation of China [2003-44]
We reported previously that regenerated Antheraea pernyi silk fibroin ( A. pernyi SF) could support the attachment and growth of human bone marrow mesenchymal stem cells (hBMSCs). In this work, the immunosupressive effects of hBMSCs cultured on the A. pernyi SF films on T-cells were investigated in vitro. The production of IL-6, CD80, CD86 and HLA-DR by the hBMSCs was also observed. The study showed that hBMSCs cultured on the regenerated A. pernyi SF films still kept their immunosupression on T-cell proliferation and IL-2 secretion. Moreover, regenerated A. pernyi SF like regenerated Bombyx mori SF and collagen did not elicit T-cell proliferation but it could support the expression of IL-6 and surface antigen of hBMSCs. Regenerated A. pernyi SF can maintain the function of hBMSCs in immunomodulation and cytokines production, which has the potential utility of hBMSCs combined with A. pernyi SF in tissue replacement and repair. (C) 2009 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
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