期刊
CELL BIOLOGY INTERNATIONAL
卷 33, 期 5, 页码 578-585出版社
WILEY
DOI: 10.1016/j.cellbi.2009.02.006
关键词
Filopodia; Overexpression; Adhesion; Migration
类别
资金
- National Natural Science Foundation of China [30670689]
- Program for New Century Excellent Talents in University [NCET-07-0173]
- Specialized Research Fund for the Doctoral Program of High Education [20060200008]
- Ministry of Education of China
Myosin X (Myo X), an unconventional myosin with a tail homology 4-band 4.1/ezrin/radixin/moesin (MyTH4-FERM) tail, is expressed ubiquitously in various mammalian tissues. In addition to the full-length Myo X (Myo X FL), a headless form is synthesized in the brain. So far, little is known about the function of this motor-less Myo X. In this study, the role of the headless Myo X was investigated in immortalized gonadotropin-releasing hormone (GnRH) neuronal cells, NLT. NLT cells overexpressing the headless Myo X formed fewer focal adhesions and spread more slowly than the wild-type NLT cells and GFP-expressing NLT cells. In chemomigration assays, the NLT cells overexpressing the headless Myo X migrated shorter distances and had fewer migratory cells compared with the control NLT cells. (C) 2009 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据