期刊
DEVELOPMENT
卷 130, 期 21, 页码 5217-5227出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.00678
关键词
transcriptional regulation; cell specification; zinc finger proteins; TEF; RFX factors; polycystins
资金
- NIDDK NIH HHS [1P50DK57325] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P50DK057325] Funding Source: NIH RePORTER
Caenorhabditis elegans polycystins LOV-1 and PKD-2 are expressed in the male-specific HOB neuron, and are necessary for sensation of the hermaphrodite vulva during mating. We demonstrate that male vulva location behavior and expression of lov-1 and pkd-2 in the ciliated sensory neuron HOB require the activities of transcription factor EGL-46 and to some extent also EGL-44. This EGL-46-regulated program is specific to HOB and is distinct from a general ciliogenic pathway functioning in all ciliated neurons. The ciliogenic pathway regulator DAF-19 affects downstream components of the HOB-specific program indirectly and is independent of EGL-46 activity. The sensory function of HOB requires the combined action of these two distinct regulatory pathways.
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