期刊
CELL BIOLOGY INTERNATIONAL
卷 32, 期 1, 页码 157-162出版社
WILEY
DOI: 10.1016/j.cellbi.2007.08.021
关键词
Kaposi sarcoma; Immune cell infiltrate; Nodular lesions
类别
Typically, Kaposi's sarcoma (KS) also presents with immune cell infiltrates. This study does immunophenotype characterization for demographics of some of these cells to test the hypothesis that 'development of end-stage (nodular/ tumor) KS is associated with numeric alteration in immune cell infiltrates.' Fifteen cases of classic-KS (nodular/ tumor) and 20 normal biopsies were examined using antigen-antibody reactions and immunoperoxidase staining for histiocytes (CD68), B cells (CD20) and T cells (CD3). Variations between normal and lesions were observed with significant increases in immune cell infiltrates (2.3 +/- 0.6 vs. 6.4 +/- 0.4); CD68(+) (4.0 +/- 1.0 vs. 7.0 +/- 0.5); CD3(+) (3.0 +/- 1.1 vs. 10.1 +/- 0.8); and CD20(+) (0.0 +/- 0.0 vs. 0.3 +/- 0.0). Increased density of immune cells in the nodular lesions of KS may reflect increased antigenicity of these lesions; the increase in T cells suggests enhanced T cell activity in KS. However, these issues should be tested by further studies. (C) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
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