期刊
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
卷 168, 期 11, 页码 1346-1352出版社
AMER THORACIC SOC
DOI: 10.1164/rccm.200306-837OC
关键词
antigen presentation; CD4-positive T lymphocytes; CD8-positive T lymphocytes; cytotoxic T lymphocytes
资金
- NIAID NIH HHS [R01AI48090, 1K08AI01644, 1KO8AI01645] Funding Source: Medline
- NICHD NIH HHS [HD33703] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI048090, K08AI001644, K08AI001645] Funding Source: NIH RePORTER
Both CD4(+) and CD8(+) T cells are important for successful immunity to tuberculosis and have redundant effector functions, such as cytolysis and release of potent antimycobacterial cytokines such as interferon-gamma and tumor necrosis factor-alpha. We hypothesized that CD8(+) T cells play a unique role in host defense to Mycobacterium tuberculosis infection as well. Possibilities include preferential and/or enhanced release of granular constituents and/or preferential recognition of heavily infected cells. Utilizing human, Mycobacterium tuberculosis-specific, CD4(+) and CD8(+) T cell clones, we demonstrate that, after recognition of antigen-presenting cells displaying peptide antigen, CD4(+) T cells preferentially release interferon-gamma, whereas CD8(+) T cells preferentially lyse antigen-presenting cells. Furthermore, utilizing dendritic cells infected with Mycobacterium tuberculosis expressing green fluorescent protein, we show that CD8(+) T cells preferentially recognize heavily infected cells that constitute the minority of infected cells. These data support the hypothesis that the central role of CD8(+) T cells in the control of infection with Mycobacterium tuberculosis may be that of surveillance; in essence, recognition of cells in which the containment of Mycobacterium tuberculosis is no longer effective.
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