期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 123, 期 5, 页码 903-905出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2003.04719.x
关键词
thrombocytopenia; adenovirus; toxicity; platelet survival; primates
类别
A replication-incompetent adenovirus vector was administered to rhesus macaques at 1, 3 and 6 x 10(12) particles/kg doses to investigate its toxicity. Platelet count decrements of 28%, 82% and 90%, respectively, were observed, with corresponding platelet half-lives of 69.0, 25.2 and 22.2 h (compared with 111 h in untreated animals). The platelet decline was equivalent for all three doses for 8 h, and platelet count recovery began as early as 8 h after infusion for low-dose recipients, or as late as 24 h for the medium and high dose recipients. These observations suggest that thrombocytopenia is a saturable, reversible consumptive process.
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