期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 17, 期 1, 页码 191-195出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1460-9568.2003.02443.x
关键词
addiction; cocaine; dependence; intracranial self-stimulation (ICSS) reward; rat; withdrawal
资金
- NIDA NIH HHS [DA04398, R56 DA011946, DA11946] Funding Source: Medline
- NATIONAL INSTITUTE ON DRUG ABUSE [R56DA011946, R01DA004398, R01DA011946] Funding Source: NIH RePORTER
This study investigated the effects of self-administered cocaine on brain reward function, measured by intracranial self-stimulation (ICSS) reward thresholds in rats. Self-administration of 10 and 20 cocaine injections (0.25 mg per injection, equivalent to 4.94 +/- 0.23 and 9.88 +/- 0.46 mg/kg, self-administered over 40 +/- 6.9 and 99 +/- 11.9 min, respectively) lowered reward thresholds 15 min later, indicating a facilitation of rewarding ICSS, but had no effect at 2, 24 or 48 h after administration. Thus, self-administration of low cocaine doses did not cause persistent changes in brain reward function. Forty cocaine injections (19.64 +/- 0.94 mg/kg; self-administered over 185 +/- 10.9 min) also transiently lowered reward thresholds 15 min later, while significant threshold current elevations were observed at 2 and 24 h after administration, indicating persistent withdrawal-like reward deficits. Finally, 80 cocaine injections (39.53 +/- 1.84 mg/kg, self-administered over 376 +/- 19.9 min) significantly elevated thresholds 2 and 48 h after self-administration, but not at 24 h. Threshold currents also tended to be elevated 15 min after self-administration. Overall, these data suggest that as the amount of self-administered cocaine increases the motivation to consume further cocaine may be shifted, from obtaining the rewarding actions of cocaine to avoidance and alleviation of a cocaine-induced negative affective state.
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