期刊
NEUROSCIENCE
卷 117, 期 3, 页码 615-625出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0306-4522(02)00923-5
关键词
coordinated differentiation; retrograde signaling; simultaneous recording; mosaic postsynaptic expression; synaptogenesis
The interaction between a neuron and its target cell(s) is essential for the development of synapses. To elucidate the role of target cells in synaptogenesis, the activity of postsynaptic calcium/calmodulin-dependent protein kinase 11 (CaMKII) was manipulated in a mosaic manner and its specific effect was examined at the developing Drosophila neuromuscular junction. We found that postsynaptic expression of constitutively active CaMKII augmented the amplitude of excitatory synaptic currents (ESCs) and the frequency of miniature ESCs. It also promoted morphological maturation of presynaptic as well as postsynaptic specializations, which presumably underlie the enhancement of synaptic activities. Expression of an inhibitory peptide of CaMKII in the postsynaptic cell partially affected the synaptic maturation. These results suggest two significant functions of postsynaptic CaMKII in synaptogenesis-retrograde modulation of presynaptic properties and coordinated regulation of pre- and postsynaptic maturation. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.
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