期刊
NEUROSCIENCE
卷 118, 期 1, 页码 7-10出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0306-4522(02)00792-3
关键词
glia; functional neuronal metabolism; singlevoxel NMR spectroscopy
The metabolic events of neuronal energetics during functional activity are still partially unexplained. In particular, lactate (and not glucose) was recently proposed as the main substrate for neurons during activity [Proc Natl Aced Sci USA 91 (1994) 10625]. By means of proton magnetic resonance spectroscopy, lactate was reported to increase during the first minutes of prolonged stimulation [Proc Natl Aced Sci USA 88 (1991) 5829; J Cereb Blood Flow Metab 12 (1992) 584; Magn Reson Med 35 (1996) 143], but the studies reported thus far suffered from low temporal resolution. In the present study we used a time-resolved proton magnetic resonance spectroscopy strategy in order to analyse the evolution of lactate during the early seconds following a brief visual stimulation (event-related design). A significant decrease in lactate concentration was observed 5 s after the stimulation, while a recovering of the baseline was observed at 12 s. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.
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