A high regioselective synthesis of novel dispiro[oxindole-cyclohexanone]pyrrolidines

A simple and efficient synthesis of title compounds has been accomplished by regioselective 1,3-dipolar cycloaddition reaction of azomethine ylide generated by the decarboxylative condensation of isatin and sarcosine with (E)-2-arylidene-1-cyclohexanones. The regio and stereochemistry of products were determined by spectroscopic techniques. The synthesis proceeds in good yield to afford a series of novel dispiro[oxindole-cyclohexanone]pyrrolidines, 1-N-methyl-spiro[2.3(1)]oxindole-spiro[3.2(11)]1(11)-cyclohexanone-4-aryl-pyrrolidines.