Lack of recovery from hepatic oxidative damage in rats treated with Nigerian bonny light crude oil

The use of Nigerian bonny light crude oil (BLCO) in the treatment of gastrointestinal disorders, burns, foot ulcers and reproductive capacity is a common practice in the southern part of Nigeria. Towards understanding the mechanism and the reversibility of hepatotoxicity induced by BLCO, adult male Wistar rats were orally administered with BLCO at 0, 50, 100 and 200?mg?kg-1 for 21?days. One-half of the rats were sacrificed on day 22, whereas the remaining half stayed for an additional 21?days without treatment. Whereas the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione S-transferase were significantly (p?