期刊
CELL BIOCHEMISTRY AND FUNCTION
卷 31, 期 5, 页码 374-379出版社
WILEY-BLACKWELL
DOI: 10.1002/cbf.2905
关键词
hesperetin; glucose uptake; GLUT1; GLUT4; breast cancer cells
资金
- Methodist Hospital Research Institute
- Ernest Cockrell Jr. Distinguished Endowed Chair
- US Department of Defense [W81XWH-09-1-0212]
- National Institutes of Health [U54CA143837, U54CA151668]
- Nylands nation Finland
The flavanone hesperetin is known to decrease basal glucose uptake, although the inhibitory mechanism is largely unknown. Here, we used MDA-MB-231 breast cancer cells to investigate the molecular pathways affected by hesperetin. The results indicate that the suppression of glucose uptake is caused by the down-regulation of glucose transporter 1 (GLUT1). Hesperetin was also found to inhibit insulin-induced glucose uptake through impaired cell membrane translocation of glucose transporter 4 (GLUT4). In addition, the phosphorylation of the insulin receptor-beta subunit (IR-beta) and Akt was suppressed. Hesperetin also decreased cellular proliferation, which is likely due to the inhibition of glucose uptake. Cancer cells are highly dependent on glucose and hesperetin may, therefore, have potential application as an anticancer agent. Copyright (c) 2012 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据