期刊
CELL BIOCHEMISTRY AND FUNCTION
卷 29, 期 2, 页码 87-95出版社
WILEY
DOI: 10.1002/cbf.1725
关键词
EGF-R; urokinase plasminogen activator; nuclear factor kappa B; beta-catenin; Quercetin; c.Jun; c.Fos
资金
- Council of Scientific and Industrial research (CSIR)
Urokinase-type plasminogen activator (uPA) is a serine protease that is involved in cancer progression, especially invasion and metastasis including prostate cancer. uPA activation is mediated by transactivation of uPAR and epidermal growth factor receptor (EGF-R) in prostate cancer progression. Prostate cancer (PC-3) cells have highly invasive capacity and they express uPA and uPAR gene. PC-3 cells are treated with quercetin, which inhibits invasion and migration of PC-3 cells. Quercetin downregulates uPA, uPAR and EGF, EGF-R mRNA expressions. Quercetin inhibits cell survival factor beta-catenin, NF-kappa B and also proliferative signalling molecules such as p-EGF-R, N-Ras, Raf-1, c.Fos c.Jun and p-c.Jun protein expressions. But quercetin increased p38 mitogen-activated protein kinase protein expression. Our results suggest that quercetin inhibit migration and invasion of prostate cancer cells. It shows the value for treatment of invasive and metastasis type of prostate cancer. Copyright (C) 2011 John Wiley & Sons, Ltd.
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