期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 89, 期 1, 页码 501-512出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00868.2001
关键词
-
资金
- NEI NIH HHS [EY-07960] Funding Source: Medline
- NINDS NIH HHS [NS-10952] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY007960] Funding Source: NIH RePORTER
To investigate how neurons in cortical layer 2/3 integrate horizontal inputs arising from widely distributed sites, we combined intracellular recording and voltage-sensitive dye imaging to visualize the spatiotemporal dynamics of neuronal activity evoked by electrical stimulation of multiple sites in visual cortex. Individual stimuli evoked characteristic patterns of optical activity, while delivering stimuli at multiple sites generated interacting patterns in the regions of overlap. We observed that neurons in overlapping regions received convergent horizontal activation that generated nonlinear responses due to the emergence of large inhibitory potentials. The results indicate that co-activation of multiple sets of horizontal connections recruit strong inhibition from local inhibitory networks, causing marked deviations from simple linear integration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据