4.6 Article

Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure

出版社

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00707.2002

关键词

TNF-alpha; GADD45 beta; BAD; gene profiling

资金

  1. NHLBI NIH HHS [R01 HL039752, R01-HL-39752] Funding Source: Medline
  2. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL039752] Funding Source: NIH RePORTER
  3. NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [Z01ES050142] Funding Source: NIH RePORTER

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Dilated cardiomyopathy, a disease of unknown etiology and pathogenesis, is associated with heart failure and compensatory hypertrophy. Although cell and animal models suggest a role for altered gene expression in the transition to heart failure, there is a paucity of data derived from the study of human heart tissue. In this study, we used DNA microarray profiling to investigate changes in the expression of genes involved in apoptosis that occur in human idiopathic dilated cardiomyopathic hearts that had progressed to heart failure. We observed altered gene expression consistent with a proapoptotic shift in the TNF-alpha signaling pathway. Specifically, we found decreased expression of TNF-alpha- and NF-kappaB-induced antiapoptotic genes such as growth arrest and DNA damage-inducible (GADD)45beta, Flice inhibitory protein (FLIP), and TNF-induced protein 3 (A20). Consistent with a role for apoptosis in heart failure, we also observed a significant decrease in phosphorylation of BAD at Ser-112. This study identifies several pathways that are altered in human heart failure and provides new targets for therapy.

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