4.5 Article

Effect of testosterone on the apneic threshold in women during NREM sleep

期刊

JOURNAL OF APPLIED PHYSIOLOGY
卷 94, 期 1, 页码 101-107

出版社

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00264.2002

关键词

control of breathing; hypocapnia; gender

资金

  1. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K24HL004174] Funding Source: NIH RePORTER
  2. NHLBI NIH HHS [K24-HL-04174] Funding Source: Medline

向作者/读者索取更多资源

The hypocapnic apneic threshold (AT) is lower in women relative to men. To test the hypothesis that the gender difference in AT was due to testosterone, we determined the AT during non-rapid eye movement sleep in eight healthy, nonsnoring, premenopausal women before and after 10-12 days of transdermal testosterone. Hypocapnia was induced via nasal mechanical ventilation (MV) for 3 min with tidal volumes ranging from 175 to 215% above eupneic tidal volume and respiratory frequency matched to eupneic frequency. Cessation of MV resulted in hypocapnic central apnea or hypopnea depending on the magnitude of hypocapnia. Nadir minute ventilation as a percentage of control (%(V) over dot E) was plotted against the change in end-tidal CO2 (PETCO2); %(V) over dot E was given a value of zero during central apnea. The AT was defined as the PETCO2, at which the apnea closest to the last hypopnea occurred; hypocapnic ventilatory response (HPVR) was defined as the slope of the linear regression (V) over dot E vs. PETCO2. Both the AT (39.5 +/- 2.9 vs. 42.1 +/- 3.0 Torr; P = 0.002) and HPVR (0.20 +/- 0.05 vs. 0.33 +/- 0.11%(V) over dot E/Torr; P = 0.016) increased with testosterone administration. We conclude that testosterone administration increases AT in premenopausal women, suggesting that the increased breathing instability during sleep in men is related to the presence of testosterone.

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