期刊
CELL BIOCHEMISTRY AND FUNCTION
卷 27, 期 7, 页码 496-498出版社
WILEY
DOI: 10.1002/cbf.1600
关键词
cell adhesion molecule; synapse; hippocampus; neuron; brain
资金
- Japan Society for the Promotion of Science [21500323]
- Salt Science Research Foundation [0838]
- Grants-in-Aid for Scientific Research [21500323] Funding Source: KAKEN
IgLON cell adhesion molecules (CAMs) belonging to the immunoglobulin superfamily comprise of LAMP, neurotrimin (Ntm), OBCAM, and Kilon. In the present study, we performed the single and double transfection of IgLON gene constructs into hippocampal neurons ill vitro and evaluated synaptic number. The quantitative analysis showed that the single over-expression of LAMP or OBCAM increased synaptic number, while the over-expression of Kilon reduced synaptic number and Ntm had no effects. The double over-expression of Kilon-Ntm, Kilon-OBCAM, LAMP-Ntm, and Ntm-OBCAM decreased synaptic number and that of Kilon-LAMP and LAMP-OBCAM had no effect. These results suggest that IgLON CAMS participate in regulating synapse formation in hippocampal neurons. Copyright (C) 2009 John Wiley & Sons, Ltd.
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