期刊
CELL BIOCHEMISTRY AND FUNCTION
卷 26, 期 8, 页码 866-869出版社
WILEY
DOI: 10.1002/cbf.1518
关键词
skeletal muscle; C2C12; ERK; MAP kinase; Cyclosporin-A; stretch
资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [48S/15855]
Activation of specific mitogen-activated protein kinases (MAPKs) has been suggested to be involved in phenotype modulation of cells Subjected to mechanical strain. which may be common to different mechano-sensitive cell types. We have submitted C2C12 myocytes to a static stretch and examined its effect upon the activation of ERK. Stretch induced a rapid but transient activation of ERK. This activation was however prevented when cells were pre-treated with inhibitors of p38 and calcineurin. The dependence of strain-induced ERK activation upon p38 Suggests a cross-talk between these two pathways when mediating a response to a mechanical stimulus in this cell type. This suggests that cross relationships between these MAP kinases may be of crucial importance for myocyte phenotype modulation and differentiation in response to a mechanical stimulus. Copyright (C) 2008 John Wiley & Sons, Ltd.
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