期刊
ELECTROPHORESIS
卷 24, 期 21, 页码 3563-3576出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elps.200305584
关键词
biological assays; microfluidics; miniaturization; poly(dimethylsiloxane); review
资金
- NIGMS NIH HHS [GM 65364] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM065364] Funding Source: NIH RePORTER
This review describes microfluidic systems in poly(dimethylsiloxane) (PDMS) for biological studies. Properties of PDMS that make it a suitable platform for miniaturized biological studies, techniques for fabricating PDMS microstructures, and methods for controlling fluid flow in microchannels are discussed. Biological procedures that have been miniaturized into PDMS-based microdevices include immunoassays, separation of proteins and DNA, sorting and manipulation of cells, studies of cells in microchannels exposed to laminar flows of fluids, and large-scale, combinatorial screening. The review emphasizes the advantages of miniaturization for biological analysis, such as efficiency of the device and special insights into cell biology.
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