期刊
JOURNAL OF CELL SCIENCE
卷 116, 期 21, 页码 4277-4281出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.00816
关键词
cytokinesis; Rho GTPase; PBL/Ect2 RhoGEF; contractile ring; PAV-KLP/MKLP1; central spindle; microtubules
类别
Despite a century of research into the nature of animal cell division, a molecular explanation for the positioning of the actomyosin contractile ring has remained elusive. The discovery of a novel interaction between regulators of Rho family small GTPases has revealed a link between the mitotic microtubules and the contractile ring during the later stages of mitosis. The properties of the interacting Rho regulators suggest a molecular model for the positioning and initiation of contractile ring furrowing in animal cells. In this 'double ring' model, centralspindlin complexes, localized by the action of their kinesin-like protein component, position and activate a cortical equatorial ring of Rho GTPase exchange factors. The resulting ring of activated Rho would then trigger a cascade of events leading to formation and constriction of the contractile ring.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据