期刊
NEUROIMAGE
卷 18, 期 1, 页码 1-9出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/nimg.2002.1314
关键词
cerebral blood flow; functional activation; laser-Doppler flowmetry; nitric oxide; nitric oxide synthase; nitric oxide microelectrode
资金
- NEI NIH HHS [EY09269] Funding Source: Medline
- NIMH NIH HHS [MH59934, MH12078] Funding Source: Medline
- NINDS NIH HHS [NS337859] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY009269] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH059934, F30MH012078] Funding Source: NIH RePORTER
We report the first dynamic measurements of tissue nitric oxide (NO) during functional activation of rat somatosensory cortex by electrical forepaw stimulation. Cortical tissue NO was measured electrochemically with rapid-responding recessed microelectrodes (tips < 10 mum). Simultaneous blood flow measurements were made by laser-Doppler flowmetry (LDF). NO immediately increased, reaching a peak 125.5 +/- 32.8 (SE) nM above baseline (P < 0.05) within 400 ms after stimulus onset, preceding any LDF changes, and then returned close to prestimulus levels after 2 s (123 signal-averaged trials, 12 rats). Blood flow began rising after a 1-s delay, reaching a peak just before electrical stimulation was ended at t = 4 s. A consistent poststimulus NO undershoot was observed as LDF returned to baseline. These findings complement our previous study (B. M. Ances et aL, 2001, Neurosci. Lett. 306,106-110) in which a transient decrease in rat somatosensory cortex tissue oxygen partial pressure was found to precede blood flow increases during functional activation. (C) 2002 Elsevier Science (USA).
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