期刊
JOURNAL OF NATURAL PRODUCTS
卷 66, 期 1, 页码 103-107出版社
AMER CHEMICAL SOC
DOI: 10.1021/np0203990
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资金
- NCI NIH HHS [P01 CA048112, P01 CA48112] Funding Source: Medline
- NIAID NIH HHS [R01 AI036596] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P01CA048112] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI036596] Funding Source: NIH RePORTER
Two new compounds, pulveraven A (1) and pulveraven B (2), as well as vulpinic acid (3) and its previously unreported polymorph were isolated from the fruiting body of Pulveroboletus ravenelii. The structures were determined using a combination of NMR, MS, IR, optical rotation, molecular modeling, and X-ray analysis. The isolates were evaluated for antimicrobial activity as well as their potential to inhibit cyclooxygenase (COX) activity and carcinogen-induced preneoplastic lesion formation with mouse mammary organ culture (MMOC).
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