期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 77, 期 1, 页码 160-166出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/77.1.160
关键词
hydrophilic antioxidants; lipophilic antioxidants; gamma-tocopherol; smokers; passive smokers; environmental tobacco smoke; body mass index; dietary micronutrients
资金
- NCI NIH HHS [1R03 CA96412-01] Funding Source: Medline
- NIEHS NIH HHS [P30 ES001896] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R03CA096412] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES001896] Funding Source: NIH RePORTER
Background: Free radicals in cigarette smoke may cause oxidative damage to macromolecules, contributing to cardiovascular diseases and cancer. Decreased plasma antioxidant concentrations may indicate cigarette smoke-related oxidative stress. Objective: We compared the effects on plasma antioxidant concentrations in cotinine-confirmed active and passive smokers with those in nonsmokers, independent of differences in dietary intakes and other covariates. Design: Plasma samples from 83 smokers, 40 passive smokers, and 36 nonsmokers were analyzed for total ascorbic acid, alpha- and gamma-tocopherols, 5 carotenoids, retinol, and cotinine. Groups were compared by using analysis of variance with adjustment for sex, age, race, body mass index, alcohol intake, triacylglycerol concentration, fruit and vegetable intakes, and dietary antioxidants. Results: After adjustment for dietary antioxidant intakes and other covariates, smokers and passive smokers had significantly lower plasma P-carotene concentrations than did nonsmokers (0.15, 0.17, and 0.24 mumol/L, respectively) and significantly higher gamma-tocopherol concentrations (7.8, 7.8, and 6.5 mumol/L, respectively). Smokers had significantly lower plasma ascorbic acid and beta-cryptoxanthin concentrations than did nonsmokers and passive smokers (ascorbic acid: 43.6, 54.5, and 54.6 mumol/L, respectively; beta-cryptoxanthin: 0.12, 0.16, and 0.16 mumol/L, respectively) and significantly lower concentrations of lutein and zeaxanthin than did nonsmokers (0.33 compared with 0.41 mumol/L). The P values for all the differences described above were < 0.05. No significant differences in plasma concentrations of alpha-tocopherol, alpha-carotene, total carotenoids, lycopene, or retinol were observed. Conclusions: These results indicate that cigarette smokers and nonsmokers exposed to cigarette smoke have a significantly lower plasma antioxidant status than do unexposed nonsmokers, independent of differences in dietary antioxidant intakes. Further research is required to explain why plasma gamma-tocopherol concentrations were significantly higher in smokers and passive smokers than in nonsmokers.
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