期刊
LEUKEMIA & LYMPHOMA
卷 44, 期 1, 页码 139-142出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1042819021000050043
关键词
hematopoietic stem cell transplantation; prednisone; cyclosporin A; irradiation; immunosuppressive drugs
资金
- NATIONAL CANCER INSTITUTE [P30CA021765, R01CA057419] Funding Source: NIH RePORTER
- NCI NIH HHS [R01-CA57419, P30-CA21765] Funding Source: Medline
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for certain leukemias and lymphomas that prove resistant to standard chemotherapy. The immunosuppressive drugs prednisone and cyclosporin A (CsA) are routinely used during HSCT to prevent or treat graft-versus-host disease (GVHD) or to inhibit antibody-mediated inflammation. However, little is known about the direct impact of prednisone and CsA on the growth of malignant lymphoid cells in the setting of HSCT. To address this issue, we measured tumor cell growth in vitro and in vivo after treatment with prednisone and CsA, used separately, together, and in combination with irradiation. Our results showed that: (i) combinations of CsA and prednisone inhibited the growth of a variety of lymphoid tumors in vitro, particularly in combination with irradiation, and (ii) tumor size was significantly reduced in a mouse B-lymphoid tumor model following CsA or CsA plus prednisone treatments, with or without HSCT.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据