期刊
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
卷 73, 期 2, 页码 509-518出版社
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1025421911670
关键词
diclofenac; drug degradation; HPLC-MS analysis; melting point; oxidative atmosphere; thermal decomposition
The thermal behaviour of Diclofenac was investigated using Differential Scanning Calorimetry, Hot Stage Microscopy, and Thermogravimetric Analysis. A discrepancy was observed between the melting point values recorded under dynamic flow of either dry nitrogen (180degreesC) or air (160degreesC). By means of High Performance Liquid Chromatography/Mass Spectrometric analyses, it has been possible to ascribe this difference in melting points to the formation of three degradation products as a result of intramolecular cyclization and condensation reactions during the heating process in an oxidative atmosphere.
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