期刊
ARTHRITIS RESEARCH & THERAPY
卷 5, 期 3, 页码 139-146出版社
BMC
DOI: 10.1186/ar757
关键词
HLA-B51; neutrophil; T lymphocytes; treatment; tumor necrosis factor alpha
类别
Behcet's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behcet's disease was estimated to be only 19%. The production of a variety of cytokines by T cells activated with multiple antigens has been shown to play a pivotal role in the activation of neutrophils. As regards the treatment, anti-tumor necrosis factor alpha therapy has been shown to be effective for mucocutaneous symptoms as well as for sight-threatening panuveitis, although a randomized, controlled trial is required.
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