期刊
ARTHRITIS RESEARCH & THERAPY
卷 5, 期 2, 页码 R74-R81出版社
BIOMED CENTRAL LTD
DOI: 10.1186/ar616
关键词
adhesion molecule; fibroblast; IFN-gamma inducible protein-10; rheumatoid arthritis
类别
Chemokines play an essential role in the progression of rheumatoid arthritis ( RA). In the present study we examined the expression and regulatory mechanisms of IFN-gamma inducible protein (IP)-10 in RA synovitis. RA synovial fluid contained greater amounts of IP-10 than did synovial fluid from patients with osteoarthritis. Immunolocalization analysis indicated that IP-10 was associated mainly with infiltrating macrophage-like cells, and fibroblast-like cells in the RA synovium. The interaction of activated leukocytes with fibroblast-like synoviocytes resulted in marked increases in IP-10 expression and secretion. Moreover, induction of IP-10 was mediated via specific adhesion molecules, as indicated by the finding that both anti-integrin ( CD11b and CD18) and intercellular adhesion molecule-1 antibodies significantly inhibited IP-10 induction. These results suggest that IP-10 expression within inflamed joints appears to be regulated not only by inflammatory cytokines but also by the physical interaction of activated leukocytes with fibroblast-like synoviocytes, and that IP-10 may contribute to the recruitment of specific subpopulations of T cells ( Th1 type) from the bloodstream into the synovial joints.
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