期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 33, 期 1, 页码 162-171出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/immu.200390019
关键词
dendritic cell; CTL; cytokine; cellular proliferation; cancer
类别
Dendritic cells (DC) play a crucial role in controlling the initiation and orientation of antigen (Ag)-specific immune responses. It is widely accepted that optimal T cell priming requires mature DC. Although the molecular events associated with DC activation have been extensively studied, little is known about the consequences of DC maturation on recruitment and expansion of naive T cells. In the present study, we used a model tumor Ag to show that the kinetics of human DC maturation drastically affect the induction of Ag-specific effector CD8(+) T cells. In absence of exogenous cytokines and CD4 help, only DC at early stages of maturation were able to generate high frequencies of CTL. This expansion resulted from both enhanced recruitment and intense proliferation of T cell precursors and could lead to an increase of up to 1,000-fold in the final number of effector T cells compared to non-matured DC. In our model, larger recruitment of naive CD8(+) cells did not modify the overall avidity of the Ag-specific T cell population.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据