期刊
SYNTHESIS-STUTTGART
卷 -, 期 2, 页码 185-194出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2003-36812
关键词
nucleophilic trifluoromethylation; trifluoromethyl anion; fluoroform; fluoral hemiaminals; alpha,alpha-difluoromethyl esters/amides
Apart from the use of (trifluoromethyl)trimethylsilane, the scope of which has been broadened to the synthesis of trifluoromethyl sulfides, especially those that are bio-active, new and mild processes for the nucleophilic trifluoromethylation of non-enolizable carbonyl compounds or disulfides have been discovered from fluoroform or hemiaminals of trifluoroacetaldehyde and their derivatives. Very stable hemiaminals of fluoral (as well as their silyl ethers), readily prepared from commercially available hemiketals, have been designed as new trifluoromethylating agents. Besides their trifluoromethylating ability, they can be transformed into silyl or methyl ethers, which behave, as efficient generators of alpha-(trifluoromethyl)iminiums salts and equivalents of difluoromethylcarboxyl anions, respectively. 1 Introduction 2 Sulfur Trifluoromethylation with CF3SiMe3 3 Trifluoromethylation with Fluoroform 4 Trifluoromethylation with Stable Hemiaminals of Fluoral 5 Generation and Uses of Fluoral Iminiums 6 Generation and Uses of Difluorocarboxylate Anions 7 Conclusion.
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