期刊
CELL BIOCHEMISTRY AND BIOPHYSICS
卷 55, 期 3, 页码 127-139出版社
HUMANA PRESS INC
DOI: 10.1007/s12013-009-9062-7
关键词
Calcium-activated potassium channels; Synaptic transmission; Synaptic plasticity; Afterhyperpolarisation; Dendritic integration; Learning and memory; Hippocampus; Amygdala; Midbrain dopaminergic neurons
Small conductance (SK) channels are calcium-activated potassium channels that, when cloned in 1996, were thought solely to contribute to the afterhyperpolarisation that follows action potentials, and to control repetitive firing patterns of neurons. However, discoveries over the past few years have identified novel roles for SK channels in controlling dendritic excitability, synaptic transmission and synaptic plasticity. More recently, modulation of SK channel calcium sensitivity by casein kinase 2, and of SK channel trafficking by protein kinase A, have been demonstrated. This article will discuss recent findings regarding the function and modulation of SK channels in central neurons.
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