期刊
JOURNAL OF NATURAL PRODUCTS
卷 66, 期 1, 页码 73-79出版社
AMER CHEMICAL SOC
DOI: 10.1021/np020342d
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资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM060600] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM 60600] Funding Source: Medline
Four new rosigenin analogues (massarigenins A-D; 1-4) and two new aromatic polyketide-derived secondary metabolites (massarinins A and B; 6, 7) and have been isolated from the freshwater aquatic fungus Massarina tunicata. The structures of these compounds were determined primarily by analysis of NMR data, and that of compound 1 was verified by X-ray crystallography. The known compound 4-(2-hydroxybutynoxy)benzoic acid (11) was also obtained, and its absolute stereochemistry was assigned. Several of these metabolites showed antibiotic activity against Gram-positive bacteria.
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