期刊
CELL AND TISSUE RESEARCH
卷 355, 期 3, 页码 515-522出版社
SPRINGER
DOI: 10.1007/s00441-014-1843-7
关键词
VE-cadherin; Cell-to-cell junctions; Endothelium; Permeability; Angiogenesis
类别
资金
- Fondation Leducq Transatlantic Network of Excellence
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- Special ProgramMolecular Clinical Oncology
- European Community [ENDOSTEM-HEALTH-2009-241440, JUSTBRAIN-HEALTH-2009-241861]
- European Research Council (ERC)
- CARIPLO Foundation
Although being a monolayer the vascular endothelium controls fundamental vessel functions such as permeability, leukocyte extravasation and angiogenesis. The endothelial selective transmembrane constituent of adherens junctions, Vascular Endothelial- (VE-) cadherin plays a crucial role in the regulation of such activities. The signaling pathways controlled by VE-cadherin as well as the ones that regulate VE-cadherin activity start to be elucidated. This delineates a complex network of molecular and functional interactions that can be altered in pathologies.
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