期刊
CELL AND TISSUE RESEARCH
卷 355, 期 3, 页码 647-656出版社
SPRINGER
DOI: 10.1007/s00441-014-1809-9
关键词
Neutrophil; Endothelial cell; Pericytes; Inflammation; Monocyte
类别
资金
- NHLBI
- NIH [HL-36028]
- American Heart Association [11POST7730055]
- National Research Fund, Luxembourg
- Marie Curie Actions of the European Commission (FP7-COFUND)
The immune cell system is a critical component of host defense. Recruitment of immune cells to sites of infection, immune reaction, or injury is complex and involves coordinated adhesive interactions between the leukocyte and the endothelial cell monolayer that lines blood vessels. This article reviews basic mechanisms in the recruitment of leukocytes to tissues and then selectively reviews new concepts that are emerging based on advances in live cell imaging microscopy and mouse strains. These emerging concepts are altering the conventional paradigms of inflammatory leukocyte recruitment established in the early 1990s. Indeed, recent publications have identified previously unrecognized contributions from pericytes and interstitial leukocytes and their secreted products that guide leukocytes to their targets. Investigators have also begun to design organs on a chip. Recent reports indicate that this avenue of research holds much promise.
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