期刊
CELL AND TISSUE RESEARCH
卷 355, 期 3, 页码 727-737出版社
SPRINGER
DOI: 10.1007/s00441-014-1853-5
关键词
Endothelium; Mechanics; Glycocalyx; Cortex; Nucleus
类别
资金
- Deutsche Forschungsgemeinschaft [OB63/18]
- Cells-in-Motion Cluster of Excellence [EXC 1003 - CIM]
- Programm fur innovative medizinische Forschung [I-FE220904, I-LI211304]
The mechanical characteristics of endothelial cells reveal four distinct compartments, namely glycocalyx, cell cortex, cytoplasm and nucleus. There is accumulating evidence that endothelial nanomechanics of these individual compartments control vascular physiology. Depending on protein composition, filament formation and interaction with cross-linker proteins, these four compartments determine endothelial stiffness. Structural organization and mechanical properties directly influence physiological processes such as endothelial barrier function, nitric oxide release and gene expression. This review will focus on endothelial nanomechanics and its impact on vascular function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据