期刊
LEUKEMIA & LYMPHOMA
卷 44, 期 3, 页码 543-545出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1042819021000037895
关键词
multiple myeloma; MGUS; acromegaly; IGF-I; GH
We present a female patient with monoclonal gammopathy of undetermined significance who has remained stable for five years but evolved to overt myeloma in strict temporal relationship with the diagnosis of GH-secreting pituitary macroadenoma. IGF-I serum levels correlated with serum and urine M component. Since the in vitro role of IGF-I on proliferation and survival of normal and neoplastic plasma cells has been recently emphasized, the pathogenetic link between acromegaly and transformation of gammopathy to overt myeloma in this case is discussed.
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