期刊
CELL AND TISSUE RESEARCH
卷 354, 期 1, 页码 171-178出版社
SPRINGER
DOI: 10.1007/s00441-013-1654-2
关键词
Major depression; Learned helplessness; Animal model; Cognitive theory; Uncontrollable stress
类别
资金
- German Ministry of Education and Research (BMBF) [01GQ1003B]
The concept of learned helplessness defines an escape or avoidance deficit after uncontrollable stress and is regarded as a depression-like coping deficit in aversive but avoidable situations. Based on a psychological construct, it ideally complements other stress-induced or genetic animal models for major depression. Because of excellent face, construct, and predictive validity, it has contributed to the elaboration of several pathophysiological concepts and has brought forward new treatment targets. Whereas learned helplessness can be modeled not only in a broad variety of mammals, but also in fish and Drosophila, we will focus here on the use of this model in rats and mice, which are today the most common species for preclinical in vivo research in psychiatry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据