期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 51, 期 11, 页码 1264-1267出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.51.1264
关键词
Selaginella uncinata; uncinoside A; uncinoside B; antiviral activity
Five compounds have been isolated from the dried whole plants of Selaginella uncinata, two of them were new chromone glycosides, 5-hydroxy-2,6,8-trimethyichromone 7-O-beta-D-glucopyranoside (uncinoside A) and 5-acetoxyl-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside B). Their structures were elucidated by spectroscopic methods including one- and two-dimensional NMR techniques. The other three compounds were identified as 8-methyl eugenitol, amentoflavone and hinokiflavone. Uncinoside A and B showed potent antiviral activities against respiratory syncytial virus (RSV) with IC50 value of 6.9 and 1.3 mug/ml, moderate antiviral activities against parainfluenza type 3 virus (PIV 3) With IC50 value of 13.8 and 20.8 mug/ml, respectively.
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