期刊
JOURNAL OF LIPID RESEARCH
卷 44, 期 11, 页码 2120-2126出版社
ELSEVIER
DOI: 10.1194/jlr.M300212-JLR200
关键词
bacteriorhodopsin; cardiolipin; archaeal lipids
In the purple membrane (PM) of Halobacterium salinarum is present a phospholipid dimer consisting of sulfo-triglycosyl-diether (S-TGD-1) esterified to the phosphate group of phosphatidic acid (PA), i.e., S-TGD-1-PA, called glycocardiolipin (GlyC) (Corcelli, A., M. Colella, G. Mascolo, E P. Fanizzi, and M. Kates. A novel glycolipid and phospholipid in the purple membrane. 2000. Biochemistry. 39: 3318-3326). The GlyC content of whole cells, PM, and other cell fractions of H. salinarum have been analyzed. GlyC is a nonabundant phospholipid in H. salinarum cells, and it represents one of the major phospholipids of isolated PM.jlr In this report, we show that a) GlyC is formed during the isolation of PM, b) GlyC increase in H. salinarum cells is specifically induced by osmotic shock, and c) in correspondence with GlyC increase, a decrease of S-TGD-1 levels occurs. The changes in membrane lipid composition observed during the isolation of PM are due to de novo synthesis of GlyC from S-TGD-1.-Lobasso S., P. Lopalco, V. M. T. Lattanzio, and A. Corcelli. Osmotic shock induces the presence of glycocardiolipin in the purple membrane of Halobacterium salinarum.
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