期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 62, 期 11, 页码 1087-1095出版社
AMER ASSN NEUROPATHOLOGISTS INC
DOI: 10.1093/jnen/62.11.1087
关键词
Alzheimer; cognition; normal aging
资金
- NIA NIH HHS [AG 06786, AG 16574] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [P50AG016574, U01AG006786] Funding Source: NIH RePORTER
Despite general agreement about the boundaries of Alzheimer disease (AD), establishing a maximum limit for Alzheimer-type pathology in cognitively intact individuals might aid in defining more precisely the point at which Alzheimer pathology becomes clinically relevant. In this study, we examined the neuropathological changes in the brains of 39 longitudinally followed, cognitively normal elderly individuals (24 women, 15 men; age range 74-95, median 85 years). Neuropathological changes of the Alzheimer type were quantified by determining neurofibrillary tangle (NFT) staging by the method of Braak and Braak and by quantification of the abundance of diffuse, cored, and neuritic plaque burden using the scheme developed by the Consortium to Establish a Registry for Alzheimer Disease (CERAD). Vascular, Lewy body, and argyrophilic grain pathology were also assessed. We found 34 subjects (87%) with a Braak stage
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