期刊
CELL AND TISSUE RESEARCH
卷 347, 期 1, 页码 257-265出版社
SPRINGER
DOI: 10.1007/s00441-011-1194-6
关键词
Aging; Bone morphogenetic protein; Osteoarthritis; Osteophyte; Signalling; Smad; Transforming growth factor-beta
类别
资金
- Netherlands Organization for Scientific Research (MW-NWO)
- Centre for Biomedical Genetics
Osteoarthritis (OA) is a disease of articular cartilage, with aging as the main risk factor. In OA, changes in chondrocytes lead to the autolytic destruction of cartilage. Transforming growth factor-beta has recently been demonstrated to signal not only via activin receptor-like kinase 5 (ALK5)-induced Smad2/3 phosphorylation, but also via ALK1-induced Smad1/5/8 phosphorylation in articular cartilage. In aging cartilage and experimental OA, the ratio ALK1/ALK5 has been found to be increased, and the expression of ALK1 is correlated with matrix metalloproteinase-13 expression. The age-dependent shift towards Smad1/5/8 signalling might trigger the differentiation of articular chondrocytes with an autolytic phenotype.
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