期刊
CELL AND TISSUE RESEARCH
卷 344, 期 3, 页码 365-379出版社
SPRINGER
DOI: 10.1007/s00441-011-1166-x
关键词
Golgi matrix; GRASP; Golgin; Rab; Trafficking
类别
资金
- National Institutes of Health [GM087364]
- American Cancer Society [RGS-09-278-01-CSM]
- University of Michigan
The eukaryotic Golgi apparatus is characterized by a stack of flattened cisternae that are surrounded by transport vesicles. The organization and function of the Golgi require Golgi matrix proteins, including GRASPs and golgins, which exist primarily as fiber-like bridges between Golgi cisternae or between cisternae and vesicles. In this review, we highlight recent findings on Golgi matrix proteins, including their roles in maintaining the Golgi structure, vesicle tethering, and novel, unexpected functions. These new discoveries further our understanding of the molecular mechanisms that maintain the structure and the function of the Golgi, as well as its relationship with other cellular organelles such as the centrosome.
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