期刊
CELL AND TISSUE RESEARCH
卷 343, 期 1, 页码 189-199出版社
SPRINGER
DOI: 10.1007/s00441-010-1033-1
关键词
High-mobility group box 1 (HMGB1); Innate immunity; Damage-associated molecular patterns (DAMPs)
类别
资金
- Ministero della Salute
- AIRC (Associazione Italiana per la Ricerca sul Cancro)
- MIUR
Damage-associated molecular patterns (DAMPs) comprise intracellular molecules characterized by the ability to reach the extracellular environment, where they prompt inflammation and tissue repair. The high-mobility box group 1 (HMGB1) protein is a prototypic DAMP and is highly conserved in evolution. HMGB1 is released upon cell and tissue necrosis and is actively produced by immune cells. Evidence suggests that HMGB1 acts as a key molecule of innate immunity, downstream of persistent tissue injury, orchestrating inflammation, stem cell recruitment/activation, and eventual tissue remodeling.
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