期刊
CELL AND TISSUE RESEARCH
卷 339, 期 1, 页码 19-29出版社
SPRINGER
DOI: 10.1007/s00441-009-0841-7
关键词
Hypoxia; Hypoxia-inducible factor; Extracellular matrix; Cartilage; Joint
类别
资金
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR048191] Funding Source: NIH RePORTER
- NIAMS NIH HHS [R01 AR048191, R01 AR048191-08] Funding Source: Medline
Low oxygen tension, i.e., hypoxia, is a pathophysiological component involved in many human disorders but is also a critically important phenomenon in normal development and differentiation. The ability of cells to survive under hypoxia or to adapt to it depends on a family of hypoxia-inducible transcription factors (HIFs) that induce the expression of a number of genes involved in hematopoiesis, angiogenesis, iron transport, glucose utilization, resistance to oxidative stress, cell proliferation, survival and apoptosis, and extracellular matrix homeostasis. We introduce here the recently identified molecular mechanisms responsible for the oxygen-dependent stability and activity of HIF, after which we focus on extracellular matrix genes as HIF targets. The vital role of the hypoxia response pathway in chondrogenesis and joint development is then discussed.
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