期刊
CELL AND TISSUE RESEARCH
卷 339, 期 1, 页码 247-257出版社
SPRINGER
DOI: 10.1007/s00441-009-0844-4
关键词
Collagens; Extracellular matrix; Fibrils; FACITs; Basement membrane
类别
资金
- NIH [EY009056, U54AR055073]
- NATIONAL EYE INSTITUTE [R01EY009056] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [U54AR055073] Funding Source: NIH RePORTER
The collagens represent a family of trimeric extracellular matrix molecules used by cells for structural integrity and other functions. The three a chains that form the triple helical part of the molecule are composed of repeating peptide triplets of glycine-X-Y. X and Y can be any amino acid but are often proline and hydroxyproline, respectively. Flanking the triple helical regions (i.e., Col domains) are nonglycine-X-Y regions, termed non-collagenous domains. These frequently contain recognizable peptide modules found in other matrix molecules. Proper tissue function depends on correctly assembled molecular aggregates being incorporated into the matrix. This review highlights some of the structural characteristics of collagen types I-XXVIII.
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