期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 285, 期 6, 页码 G1204-G1213出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00132.2003
关键词
nodose ganglia; Na+ current; hyperpolarization-activated current; capsaicin
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS020561] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS-20561] Funding Source: Medline
Patch-clamp electrophysiological methods were used on dissociated rat nodose neurons maintained in culture to determine whether responses to cholecystokinin (CCK) were associated with capsaicin-resistant ( A type) or capsaicin-sensitive ( C type) neurons. Nodose neurons were classified as A or C type on the basis of the characteristics of the Na+ current, a hyperpolarization-activated current, and sensitivity to a low concentration of capsaicin to ascertain the presence of vanilloid receptor 1 that has been associated with C-type neurons in sensory ganglia. It was expected that only capsaicin-sensitive C-type neurons would respond to CCK, because most vagally mediated actions of CCK are blocked by capsaicin treatment. However, we found that subpopulations of both A- and C-type neurons responded to CCK ( 24 and 38%, respectively). Thus some vagally mediated actions of CCK may be mediated by capsaicin insensitive A- type neurons.
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