4.4 Review

Endothelial transcytosis in health and disease

期刊

CELL AND TISSUE RESEARCH
卷 335, 期 1, 页码 27-40

出版社

SPRINGER
DOI: 10.1007/s00441-008-0688-3

关键词

Transcytosis; Endothelium; Caveolae; Plasma proteins; Disease

资金

  1. NIH-USA
  2. European Community
  3. COST Action [BM0602]
  4. Romanian Academy and Ministry of Education and Research, Romania

向作者/读者索取更多资源

The visionaries predicted the existence of transcytosis in endothelial cells; the cell biologists deciphered its mechanisms and (in part) the molecules involved in the process; the cell pathologists unravelled the presence of defective transcytosis in some diseases. The optimistic perspective is that transcytosis, in general, and receptor-mediated transcytosis, in particular, will be greatly exploited in order to target drugs and genes to exclusive sites in and on endothelial cells (EC) or underlying cells. The current recognition that plasmalemmal vesicles (caveolae) are the vehicles involved in EC transcytosis has moved through various phases from intial considerations of caveolae as unmovable sessile non-functional plasmalemma invaginations to the present identification of a multitude of molecules and a crowd of functions associated with these ubiquitous structures of endothelial and epithelial cells. Further understanding of the molecular machinery that precisely guides caveolae through the cells so as to reach the target membrane (fission, docking, and fusion), to avoid lysosomes, or on the contrary, to reach the lysosomes, and discharge the cargo molecules will assist in the design of pathways that, by manipulating the physiological route of caveolae, will carry molecules of choice (drugs, genes) at controlled concentrations to precise destinations.

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