Infrared spectrometry based C-13-octanoic acid breath test in measuring human solid gastric emptying

Background and Aims: Because of the convenience of non-dispersive infrared spectrometry (NDIRS), we attempted to validate the usefulness of NDIRS compared with scintigraphy in human solid gastric emptying (GE) measurement, and tried to establish the normal range of solid GE based on NDIRS. Methods: Twelve healthy volunteers (three men, nine women) were recruited for simultaneous scintigraphy and (13) C-octanoic acid breath test ((13) C-OABT) studies. Stomach half-emptying time (t(1/2) ) and lag phase (t(lag) ) were the two main GE parameters measured and correlated. The breath samples were analyzed using NDIRS every 10-15 min for a total of 6 h, while scintigraphy was taken minute by minute for the first 30 min, then hourly for 4 h. Another 32 healthy volunteers (19 men, 13 women) received only the (13) C-OABT to measure their solid GE. Results: A significant correlation for t(1/2) was found between the breath test and scintigraphy (r = 0.85, P = 0.001), while t(lag) was also positively correlated (r = 0.73, P = 0.007). The reference range of t(1/2B) based on all 44 subjects was 89.4-185.1 min (135.9 +/- 21.1 min (mean +/- SD)), while the range for t(lagB) was 37.1-117.8 min (81.9 +/- 17.4 min). No demographic characteristics were found to influence the GE parameters. Conclusions: (13) C-octanoic acid breath test determined by NDIRS is a simple, non-invasive and reliable measurement, which may provide an 'office-based' tool to detect solid GE. (C) 2003 Blackwell Publishing Asia Pty Ltd.